Download PDF by Matti S. Aapro (auth.), Matti S. Aapro (eds.): Innovative Antimetabolites in Solid Tumours

By Matti S. Aapro (auth.), Matti S. Aapro (eds.)

ISBN-10: 3642792006

ISBN-13: 9783642792007

ISBN-10: 3642792022

ISBN-13: 9783642792021

The ecu institution of Oncology got here into lifestyles to reply to a necessity for info, schooling and coaching within the box of the analysis and remedy of melanoma. There are major the explanation why such an initiative used to be essential. to start with, the educating of oncology calls for a conscientiously multidisciplinary technique that is tough for the schools to place into perform due to the fact that their process is principally disciplinary oriented. Secondly, the speed of technological improvement that impinges at the prognosis and therapy of melanoma has been so fast that it's not a simple job for scientific schools to evolve their curricula flexibly. With its residential classes for organ pathologies and the seminars on new thoughts (laser, monoclonal antibodies, imaging suggestions etc.) or at the important healing controversies (conservative or mutilating surgical procedure, basic or adjuvant chemotherapy, radiotherapy by myself or integrated), it's the ambition of the eu university of Oncology to fill a cultural and clinical hole and, thereby, create a bridge among the college and and among those and day-by-day scientific perform. one of many newer projects of ESO has been the establishment of everlasting research teams, also known as activity forces, the place a constrained variety of top specialists are invited to fulfill yearly with the purpose of defining the state-of-the-art and doubtless attaining a consensus on destiny advancements in particular fields of oncology.

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Economic advantage was claimed for patients treated with chemotherapy over the cost incured for patients who received supportive care only [14]. The British Medical Research Council (MRC) is currently undertaking a meta-analysis of 11 randomised trials (8 containing cisplatin) to determine whether the difference in survival with chemotherapy is statistically significant over that of best supportive care. Recently a meta-analysis of 7 trials has been published [15]. However, the difference in median survival time is only a few months (Table 1).

REFERENCES Grever M, Leiby J, Kraut E et al: A comprehensive phase I and II clinical investigation of fludarabine phosphate. Semin Oncol 1990 (17):39-48 2 Beutler E: Cladribine (2-chlorodeoxyadenosine). Lancet 1992 (340):952-956 3 Gandhi V, Estey E, Keating MJ, Plunkett W: Fludarabine potentiates metabolism of cytarabine in patients with acute myelogenous leukemia during therapy. J Clin Oncol 1993 (11): 116-124 4 Kawasaki K, Carrera CJ, Piro LD et al: Relationship of deoxycytidine kinase and cytoplasmic 5'nucleotidase to the chemotherapeutic efficacy of 2chlorodeoxyadenosine.

Fludarabine monophosphate studies in solid tumours Tumour Lung (phase I) Breast NSCLC Ovary Head & neck Colorectum Hepatoma STS Renal cell SCLC Ovary Colorectum Glioma Breast Renal cell Head & neck Cervix Endometrium Melanoma CNS Pancreas Total Number of patients Number of responses 13 15 23 29 25 22 19 23 36 11 21 21 15 18 18 13 21 20 27 23 20 1 0 0 0 433 SCLC = small cell lung carcinoma STS = soft tissue sarcoma 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Author (ref) Hutton et al. [6] Carpenter et al. [16] Weiss et al.

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Innovative Antimetabolites in Solid Tumours by Matti S. Aapro (auth.), Matti S. Aapro (eds.)

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